Cockatrice - Cockatrice is an open-source, multiplatform program for playing tabletop card games over a network.
Evoker: Magic Card Game - Evoker: Magic Card Game is a Collectible Card, Action, Combat, Single and Multiplayer video game created and published by Flare Games.
Hearthstone - Pick up your cards and throw down the gauntlet!
XMage - XMage allows you to play Magic against one or more online players or computer opponents.
Magarena - Magarena is a single-player fantasy card game played against a computer opponent.
OCTGN - OCTGN (Online Card and Tabletop Gaming Network) is a virtual table top with an integrated player lobby and chat system that supports custom card and board games.