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LockHunter - It is a free tool to delete files blocked by something you do not know.
Malwarebytes - Malwarebytes protects you against malware, ransomware, and other advanced online threats that have made antivirus obsolete and ineffective. Free Anti-Malware & Malware .
Wise Force Deleter - Delete Any File That Windows Can’t Delete.
ESET SysRescue Live - A malware cleaning tool that runs independent of the operating system from a CD, DVD, or a USB.
FileASSASSIN - FileASSASSIN is an application that can delete any type of locked files that are on your computer.
Adware Removal Tool by TSA - Portable tool to easily get rid of hard to remove adwares, PUP, Toolbars and Hijackers.