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PySimpleGUI - A simple to use GUI that can create custom GUIs
Inkscape - Inkscape is a free, open source professional vector graphics editor for Windows, Mac OS X and Linux.
PyQt - Riverbank | Software | PyQt | What is PyQt?
Sketch - Professional digital design for Mac.
Dear PyGui - Dear PyGui is a simple to use (but powerful) Python GUI framework. Dear PyGui provides a wrapping of Dear ImGui which simulates a traditional retained mode GUI (as opposed to Dear ImGui's immediate mode paradigm).
Affinity Designer - Professional creative software, exclusively for Mac.