Vimium - The Hacker's Browser.
X-Mouse Button Control - XMouse Button Control (XMBC) allows you to create application and window specific profiles.
hunt-n-peck - Simple vimium/vimperator style navigation for Windows applications based on the UI Automation...
SteerMouse - Advanced driver for USB and Bluetooth mouses.
Tridactyl - Replace Firefox's default control mechanism with one modelled on the one true editor, Vim.
Mac Mouse Fix - A simple way to make your 3rd party mouse better.