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Maxima - Maxima is a fairly complete computer algebra system written in Lisp with an emphasis on symbolic computation.
Unity - The multiplatform game creation tools for everyone.
Wolfram Mathematica - Mathematica has characterized the cutting edge in specialized processing—and gave the chief calculation environment to a large number of pioneers, instructors, understudies, and others around the globe.
Godot Engine - Feature-packed 2D and 3D open source game engine.
QtOctave - QtOctave: a front-end for Octave/un Front-End para Octave
Blender - Blender is the open source, cross platform suite of tools for 3D creation.